Anthropic
Claude 4.8 Opus (300B)
Advanced reasoning and coding model of the Claude 4 generation
Model Summary
Family
Claude 4.8
Version
4.8
Parameters
300B (est.)
Parameter counts for closed models are estimates; vendors rarely publish exact sizes.
VRAM Requirements by Quantization
Memory needed to serve Claude 4.8 Opus (300B) for inference, including a 20% overhead for activations and KV cache.
| Precision | VRAM needed | Smallest single GPU that fits |
|---|---|---|
| INT4 (4-bit) | 167.64 GB | NVIDIA B200 SXM (192 GB) |
| INT8 (8-bit) | 335.28 GB | Multi-GPU required |
| FP16 (16-bit) | 670.55 GB | Multi-GPU required |
| FP32 (32-bit) | 1341.10 GB | Multi-GPU required |
Recommended GPU Configurations
Cheapest on-demand configurations to serve Claude 4.8 Opus (300B) at 8-bit (335 GB VRAM).
2x AMD Instinct MI300X
384 GB total VRAM · CDNA 3
~$12.00/h
2x AMD Instinct MI325X
512 GB total VRAM · CDNA 3
~$16.00/h
5x NVIDIA A100 80GB
400 GB total VRAM · Ampere
~$22.50/h
Quick GPU Planning
Use the calculator pre-filled with this exact version to estimate memory, speed, and compute requirements in a few clicks.
Access Pre-filled CalculatorFrequently Asked Questions
How much VRAM do you need to run Claude 4.8 Opus (300B)?
With an estimated 300B parameters, Claude 4.8 Opus (300B) needs roughly 335 GB of VRAM in 8-bit (INT8), 168 GB in 4-bit, and 671 GB in FP16, including a 20% overhead for activations and KV cache.
Which GPUs can run Claude 4.8 Opus (300B)?
At 8-bit quantization, the most cost-effective option is 2x AMD Instinct MI300X (384 GB combined VRAM, around $12.00/hour on-demand). Higher-end cards like the NVIDIA B200 or AMD MI355X reduce the GPU count needed.
Can Claude 4.8 Opus (300B) run on a single GPU?
Only with aggressive quantization: in 4-bit, a single NVIDIA B200 SXM (192 GB) can fit it. At 8-bit or higher, you need a multi-GPU setup.
How much does it cost to serve Claude 4.8 Opus (300B) in the cloud?
Renting 2x Instinct MI300X costs on the order of $12.00/hour, i.e. about $8,760/month running 24/7. Actual prices vary by provider and commitment; spot and reserved capacity can be significantly cheaper.
Deploy on a GPU cloud
Rent 2x Instinct MI300X by the hour instead of buying hardware.
