Anthropic
Claude 5 Opus (300B)
Frontier agentic coding model with 1M-token context, near Fable 5 quality at half the price
Model Summary
Family
Claude 5
Version
5.0
Parameters
300B (est.)
Parameter counts for closed models are estimates; vendors rarely publish exact sizes.
VRAM Requirements by Quantization
Memory needed to serve Claude 5 Opus (300B) for inference, including a 20% overhead for activations and KV cache.
| Precision | VRAM needed | Smallest single GPU that fits |
|---|---|---|
| INT4 (4-bit) | 167.64 GB | NVIDIA B200 SXM (192 GB) |
| INT8 (8-bit) | 335.28 GB | Multi-GPU required |
| FP16 (16-bit) | 670.55 GB | Multi-GPU required |
| FP32 (32-bit) | 1341.10 GB | Multi-GPU required |
Recommended GPU Configurations
Cheapest on-demand configurations to serve Claude 5 Opus (300B) at 8-bit (335 GB VRAM).
3x AMD Instinct MI250X
384 GB total VRAM · CDNA 2
~$7.50/h
21x NVIDIA T4
336 GB total VRAM · Turing · multi-node
~$10.50/h
2x AMD Instinct MI300X
384 GB total VRAM · CDNA 3
~$12.00/h
Quick GPU Planning
Use the calculator pre-filled with this exact version to estimate memory, speed, and compute requirements in a few clicks.
Access Pre-filled CalculatorFrequently Asked Questions
How much VRAM do you need to run Claude 5 Opus (300B)?
With an estimated 300B parameters, Claude 5 Opus (300B) needs roughly 335 GB of VRAM in 8-bit (INT8), 168 GB in 4-bit, and 671 GB in FP16, including a 20% overhead for activations and KV cache.
Which GPUs can run Claude 5 Opus (300B)?
At 8-bit quantization, the most cost-effective option is 3x AMD Instinct MI250X (384 GB combined VRAM, around $7.50/hour on-demand). Higher-end cards like the NVIDIA B200 or AMD MI355X reduce the GPU count needed.
Can Claude 5 Opus (300B) run on a single GPU?
Only with aggressive quantization: in 4-bit, a single NVIDIA B200 SXM (192 GB) can fit it. At 8-bit or higher, you need a multi-GPU setup.
How much does it cost to serve Claude 5 Opus (300B) in the cloud?
Renting 3x Instinct MI250X costs on the order of $7.50/hour, i.e. about $5,475/month running 24/7. Actual prices vary by provider and commitment; spot and reserved capacity can be significantly cheaper.
Deploy on a GPU cloud
Rent 3x Instinct MI250X by the hour instead of buying hardware.
